Association of Major Coronary Risk Factors and Gender
Simin Jafaripour
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Malihe Dadgarmoghaddam
Department of Community Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen Mouhebati
Department of Vascular and Cardiology, Ghaem Hospital, Mashhad, Iran.
Ariane Sadr-Nabavi *
Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran and Medical Genetic Research Center (MGRC), School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran and Iranian Academic Centers for Education, Culture and Research (ACECR), Iran.
*Author to whom correspondence should be addressed.
Abstract
Aims: The aim of this study is to compare major risk factors in Coronary Artery Disease patients with significant atherosclerotic lesions in both genders.
Study Design: Cross-Sectional study.
Place and Duration of Study: From Aug 2012 to Dec 2013, 299 consecutive patients who underwent angiography at the coronary angiography laboratory in Ghaem hospital were enrolled in this study.
Methodology: Demographic data was collected by an interviewer based on a checklist. Moreover, a member of our research group examined patients for weight, height, and blood pressure. For each patient a blood sample was taken and angiography was done by an expert. Statistical analysis was performed by SPSS version 11.5, using descriptive statistics, one-way ANOVA, and non-parametric equivalent, Kruskal- Wallis. p<0.05 was considered as statistically significant.
Results: Participants in this study were Iranian and 52.8% were female. The females were older than males (mean age 59±10.14 vs 58±12.4); and the majority of them were married and lived in urban areas. Among 169 patients that were recruited in the study, 95 (55.6%) had a positive history of hypertension (HTN), 77 (46.4%) hyperlipidemia, and 55 (32.5%) type 2 Diabetes Mellitus (T2DM). The observed differences in these parameters between two genders were significant (P<0.001, P=0.001 and P=0.001), respectively. Among the participants, 40 (46.4%) were smokers (at present or in the past).
Conclusion: Our results show that the prevalence of HLP, HTN and T2DM among Iranian women who belong to the CAD patients’ population is more than men.
Keywords: Risk factors, coronary artery disease, atherosclerotic lesion.