Relationship between Glycated Haemoglobin, Fasting Plasma Glucose, Packed Cell Volume and Albumin Creatinine Ratio in Diabetic Patients in South-South Nigeria
C. L. Sakpa
Department of Anatomy, College of Medicine, University of Benin, Benin City, Nigeria.
J. O. Idemudia *
Department of Chemical Pathology, college of Medicine, University of Benin, Benin City, Nigeria
*Author to whom correspondence should be addressed.
Abstract
The relationship between glycated haemoglobin, fasting plasma glucose, packed cell volume and albumin creatinine ratio in diabetic patients in south-south Nigeria was investigated in 118 diabetic patients (80 females and 38 males) and 36 apparently healthy controls (20 females and 16 males). The glycated haemoglobin (HbA1c), fasting blood glucose (FBG) and albumin creatinine ratio (ACR) of (6.5±0.65%, 113±7.9mgldL and 48.4±6.3 respectively) were significantly higher in the diabetic patients than in control subjects (3.7±0.13%, 86±2.6mgldL and 21.0±5.1 respectively), while the packed cell volume (PCV) was higher in the control subjects than in diabetic patients (46.3±1.13% vs 40.6±0.92%). There was a significant positive correlation between the HbA1c, and FBG in both the diabetic patients and control subjects (r=0.418 and 0.782 respectively, P<0.001) and there was also a significant positive correlation between the HbA1c and ACR in both the diabetic patients and control subjects (r= 0.244 and 0.618 respectively, P< 0.001).
In conclusion, there is a strong relationship between HbA1c, FBG and ACR in diabetic patients and control subjects.
Keywords: Diabetes mellitus, glycated haemoglobin, fasting blood glucose, packed cell volume, albumin creatinine ratio