Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients
A. F. AbdeL-Aziz
Division of Biochemistry, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Afaf EL-Saeed
Genetics Unit, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Khaled EL-Dahshan
Nephrology and Urology Hospital, Faculty of Medicine, Mansoura University, Egypt.
Basma AL-Sayed Ebead *
Division of Biochemistry, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are associated with ESRD as risk factors in several studies. In this study, we investigated the association between ACE I/D gene polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD genotype were significantly increased, while frequencies of I allele and ID genotype were significantly decreased in the ESRD patients when compared with the control subjects (P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95% CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with ESRD as risk factors for ESRD in the Egyptian population.
Keywords: Angiotensin-I-converting enzyme (I/D) polymorphism, end stage renal disease.