Effect of Xylopia aethiopica, Fiscus mucuso and Anthocleista vogelli Extracts on Some Biochemical Parameters Following Ethanol-induced Toxicity
A. O. Ayoka *
Department of Physiological Sciences, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
R. E Okonji
Department of Biochemistry, Faculty of Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
D. A. Ofusori
Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
O. A. Komolafe
Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
K. D. S. Bamitale
Department of Medical Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
J. B. Fakunle
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The objective of the study was to comparatively verify the effects of aqueous extracts of three plants on some biochemical parameters following ethanol administration with a view to ascertaining the role of the extracts in ameliorating ethanol toxicity.
A total of forty rats were divided into eight groups (n=5). Group A were control rats; Group B were administered with absolute ethanol; Group C were ethanol administered rats treated with Xylopia aethiopica; Groups D were ethanol administered rats treated with Fiscus mucuso, Group E were ethanol administered rats treated with Anthocleista vogelli; Group F were normal rats administered orally with Xylopia aethiopica; Group G were normal rats administered orally with Fiscus mucuso; Group H were normal rats administered orally with Anthocleista vogelli. At the end of the experimental period, the animals were sacrificed and serum was obtained for total protein, uric acid, creatinin, urea, aspartate aminotrasferase (AST) and alanine aminotransferase (ALT) analysis using respective research kits.
The result showed that Xylopia aethiopica had protective effect on the kidney as compared with Fiscus mucuso and Anthocleista vogelli treated rats. Also, The AST and ALT was lowered with the beginning of Xylopia aethiopia treatment. The total protein, creatinin and urea were slightly (p>0.05) affected with ethanol, an effect which was normalized with the beginning of extract treatment.
It can be concluded that Xylopia aethiopica had a better reno-protective and hepatoprotective effect than Anthocleista vogelli and Fiscus mucuso extract as evident in its ameliorative role on the biochemical profiles.
Keywords: Ethanol, Xylopia aethiopica, Fiscus mucuso, Anthocleista vogelli.