Evaluating Markers of Oxidative Stress in Managing Gestational Diabetes Mellitus: A Cross Sectional Study in Iraq
Dina Jamil
Al-Husayniya Medical Centre, Ministry of Health, Baghdad, Iraq and Diabetes Complications Research Initiative and School of Community Health, Faculty of Science, Charles Sturt University, Albury, New South Wales, Australia.
Hayder Al-Aubaid *
Diabetes Complications Research Initiative and School of Community Health, Faculty of Science, Charles Sturt University, Albury, New South Wales, Australia and School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Estabraq Al-Wasiti
Department of Chemistry and Clinical Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Mohammed Al Bayati
Department of Chemistry and Clinical Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
*Author to whom correspondence should be addressed.
Abstract
Aims: The objective of the present study was to evaluate the association of oxidative stress markers and antioxidants in gestational diabetes when compared to non-diabetic pregnant women.
Methodology: This is a cross-sectional study, conducted in Al-Husayniya Medical Centre, Baghdad, Iraq and included 73 participants attending the Maternal and Childhood Unit for the period between January 2008 and May 2010.
Results: Serum 8-Hydroxy-2-Deoxyguanosine was significantly greater in the gestational diabetes mellitus group compared to control group (57.2±17.6ng/dl versus 19.8±7.8ng/dl respectively, P<.05). The increase in 8-Hydroxy-2-Deoxyguanosine was associated with a significant elevation in serum total cholesterol and high density lipoprotein cholesterol and a significant reduction in serum superoxide dismutase in the gestational diabetes mellitus group compared to the control group at P<.05. A significant negative correlation was noted between 8-Hydroxy-2-Deoxyguanosine and superoxide dismutase among all the participants included in this study (r=0.66 at P<.05).
Conclusions: The current study proves the importance of measuring markers of oxidative stress (expressed by serum 8-Hydroxy-2-Deoxyguanosine & serum lipids) and antioxidants (expressed by serum superoxide dismutase) in managing cases of gestational diabetes mellitus and provides a useful way of assessing the disease progression and/or remission in response to the treatment.
Keywords: Gestational diabetes, oxidative DNA damage, lipid peroxidation, antioxidants.