Antidiabetic Activity of Hydroalcoholic Extracts of Nardostachys jatamansi in Alloxan-induced Diabetic Rats
M. A. Aleem *
Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India.
B. Syed Asad
Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India.
Tasneem Mohammed
Department of Gastroenterology and Hepatology, Ibn Sina National College of Medical Sciences, Al Mahjar, Jeddah-21418, K. S. A, Saudi Arabia.
Riyaz Ahmed Khan
Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India.
M. Farooq Ahmed
Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India.
A. Anjum
Department of chemistry, Asian Institute of Advance Scientific and Pharmaceutical Research, Hyderabad, Andhra Pradesh, India.
M. Ibrahim
Department of Medicinal Chemistry and Pharmacology, Nizam Institute of Pharmacy and Research Center, Deshmukhi (V), Pochampally (M), Near Ramoji Film City, Nalgonda,(AP), India-508284, India. And Department of chemistry, Asian Institute of Advance Scientific and Pharmaceutical Research, Hyderabad, Andhra Pradesh, India and Center for Liver Research and Diagnostics, Deccan College of Medical Sciences and Allied Hospitals Kanchanbagh, Hyderabad 500 058, Andhra Pradesh, India.
*Author to whom correspondence should be addressed.
Abstract
A review of literature indicates that diabetes mellitus was fairly well known and well conceived as an entity in India with complications like angiopathy, retinopathy, nephropathy, and causing neurological disorders. The antidiabetic study was carried out to estimate the anti hyperglycemic potential of Nardostachys Jatamansi rhizome’s hydro alcoholic extracts in alloxan induced diabetic rats over a period of two weeks. The hydroalcoholic extract HAE1 at a dose (500mg/kg) exhibited significant antihyperglycemic activity than extract HAE2 at a dose (500mg/kg) in diabetic rats. The hydroalcoholic extracts showed improvement in different parameters associated with diabetes, like body weight, lipid profile and biochemical parameters. Extracts also showed improvement in regeneration of β-cells of pancreas in diabetic rats. Histopathological studies strengthen the healing of pancreas by hydro alcoholic extracts (HAE1& HAE2) of Nardostachys Jatamansi, as a probable mechanism of their ant diabetic activity.
Keywords: Nardostachys jatamansi, diabetes mellitus, alloxan, hypoglycemic effect, hydroalcoholic extract.