Vitamin D Deficiency is Associated with Nonspecific Low Back Pain in Young Women, a Case-Control Study
Behzad Heidari
Department of Internal Medicine, Rouhani hospital, Babol University of Medical Sciences, Babol, Iran and Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran
Yahya Javadian *
Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran and Department of Physiotherapy, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Parham Heidari
Avina Clinic No 5, Jordan ST, Tehran, Iran Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.
Niloofar Hakimi
Imam Reza Clinic, 17 Sharivar ST, Tehran, Iran Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.
Karim Hajian-Tilaki
Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran.
Ali Reza Firouzjahi
Department of Laboratory Medicine, Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
*Author to whom correspondence should be addressed.
Abstract
Background: Vitamin D deficiency is linked to several musculoskeletal conditions including nonspecific low back pain, autoimmune diseases. Data regarding to vitamin D deficiency and low back pain are not consistent across various studies. The objective of this case-control study was to determine association of vitamin D deficiency and low back pain in women.
Methods: Eighty-one women with nonspecific low back pain and 101 age-matched controls entered the study. Serum vitamin D was assessed by quantitative determination of serum 25-hydroxyvitamin D (25-OHD) by electerochemiluminecence method, and levels <20ng/ml were considered as vitamin D deficiency. Mann-Whitney U test and chi square test was used for analysis.
Results: Mean age of patients and controls was 35.1±8.14 and 37.4±7.9 years respectively. Median serum 25-OHD concentration in patients was significantly lower than control group (p=0.003). Serum 25-OHD deficiency was observed in 57(70.4%) patients versus 47(46.5%) controls (p=0.001). There was a significant association between serum 25-OHD deficiency and low back pain (OR=2.72, 95%CI, 1.47-5, p=0.001). 25-OHD deficiency was significantly correlated with low back pain (r=0.239, p=0.001).
Conclusion: This study indicates a significant association between vitamin D deficiency and nonspecific LBP in women and justifies serum 25-OHD assessment in women with low back pain.
Keywords: Vitamin D, deficiency, low back pain, women