• Submission

Journal of Advances in Medicine and Medical Research

  • About
    • About the Journal
    • Submissions & Author Guideline
    • Articles in Press
    • Editorial Policy
    • Editorial Board Members
    • Reviewers
    • Propose a Special Issue
    • Reprints
    • Subscription
    • Membership
    • Publication Ethics and Malpractice Statement
    • Digital Archiving Policy
    • Contact
  • Archives
  • Indexing
  • Publication Charge
  • Books
  • Testimonials
Advanced Search
  1. Home
  2. Archives
  3. 2016 - Volume 14 [Issue 9]
  4. Review Article

Submit Manuscript


Subscription



  • Home Page
  • Author Guidelines
  • Editorial Board Member
  • Editorial Policy
  • Propose a Special Issue
  • Membership

Fanconi Anemia Genes and Reactive Oxygen Species in Cancer Development

  • Igor Afanas’ev

Journal of Advances in Medicine and Medical Research, Page 1-7
DOI: 10.9734/BJMMR/2016/24279
Published: 24 March 2016

  • View Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract


Fanconi Anemia (FA) is an autosomal recessive disease of childhood. However, the FA pathway is responsible for the development of leukemia and the other cancers. It has been also demonstrated that FA, an only human genomic instability syndrome is very sensitive to oxidative stress and ROS overproduction. In the present work, we consider major mechanisms of antioxidant protection in FA cells. We showed that there are two types of such mechanisms: the suppression of ROS overproduction by FA genes through the activation of basic FA anemia proteins under the conditions of oxidative stress and the application of free radical scavengers able to react with iron-dependent ROS such as flavonoids rutin and quercetin. The last nontoxic compounds of vitamin P group might be recommended for the treatment of FA anemia patients. Then, we discussed the role of FA anemia proteins in cancer development.


Keywords:
  • Fanconi anemia
  • reactive oxygen species
  • antioxidants
  • rutin
  • Full Article - PDF
  • Review History

How to Cite

Afanas’ev, I. (2016). Fanconi Anemia Genes and Reactive Oxygen Species in Cancer Development. Journal of Advances in Medicine and Medical Research, 14(9), 1-7. https://doi.org/10.9734/BJMMR/2016/24279
  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver
  • Abstract View: 377 times
    PDF Download: 166 times

Download Statistics

Downloads

Download data is not yet available.
  • Linkedin
  • Twitter
  • Facebook
  • WhatsApp
  • Telegram
Make a Submission / Login
Information
  • For Readers
  • For Authors
  • For Librarians
Current Issue
  • Atom logo
  • RSS2 logo
  • RSS1 logo


© Copyright 2010-Till Date, Journal of Advances in Medicine and Medical Research. All rights reserved.