Trisomy 21: Genetic Analysis Aided Diagnosis
Ankit Dhimole
Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, Jabalpur (M.P), India.
Sreedevi Reddy
Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, Jabalpur (M.P), India.
Anil Kumar Nagarajappa
Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, Jabalpur (M.P), India.
Nalin Saxena
Department of Oral Medicine and Radiology, Hitkarini Dental College and Hospital, Jabalpur (M.P), India.
*Author to whom correspondence should be addressed.
Abstract
Being the most common yet rare genetic syndrome in the field of dentistry Trisomy 21 also known as the Down’s syndrome named after John Langdon Down has its own importance in dentistry. It has characteristic physical, genetic and mental features which could remain undiagnosed particularly in low socio-economic group areas in countries of southern asia. Dental professionals could be the first ones to diagnose this problem as it shows unique intra-oral and extra-oral features. So we report a classic case of Down’s syndrome which remained undiagnosed throughout his life till he visited a dental professional.
Keywords: Chromosome 21, Down syndrome, Trisomy 21, chromosomal analysis, simian crease