GnRH Agonists: Are They Ready for Clinical Use as an Anti-adhesive Agent? A Review of the Literature
Viktoria–Varvara Palla *
Department of Obstetrics and Gynecology, G. Genimatas General Hospital, Athens, Greece.
Georgios Karaolanis
Department of Urology, Laiko Hospital, University of Athens, Greece.
Ioannis Katafigiotis
Department of Urology, Laiko Hospital, University of Athens, Greece.
Konstantinos Kontzoglou
Department of Surgery, Laiko General Hospital, Medical School of Athens, Athens, Greece.
Ioannis Anastasiou
Department of Urology, Laiko Hospital, University of Athens, Greece.
*Author to whom correspondence should be addressed.
Abstract
GnRH agonists have been shown to intervene in the mechanism of adhesion formation in a variety of ways. Influence on the hormonal state, the inflammatory and coagulation processes contribute to the reduction of adhesion formation postoperatively. Most studies on this topic have been conducted in animal models and have indicated the possible clinical use of GnRH agonists for this purpose. The aim of this study is to investigate the literature review of the mechanisms and the possible advantages of GnRH agonists therapy in the prevention of postoperative adhesions.
Keywords: GnRH agonists, adhesions, anti-adhesive agents, literature review