Hepatoid Carcinoma of Adrenal Gland: A Case Report
Naourez Gouiaa
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Manel Mellouli *
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Najla Abid
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Rim Kallel
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Ibticem Bahri
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Maha Kharrat
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
Jamel Ammar
Department of Urology, Habib Bourguiba University Hospital of Sfax, Tunisia
Tahiya Boudawara
Department of Pathology, Habib Bourguiba University Hospital of Sfax, Tunisia
*Author to whom correspondence should be addressed.
Abstract
Aims: Hepatoid carcinoma is a rare tumor that mimics the morphologic and immunohistochemical features of hepatocellular carcinoma. An exceptional occurrence in adrenal gland has been recorded in the literature. The aim of this work is to study the morphologic immunohistochemical differential diagnosis and prognosis of adrenal hepatoid carcinoma.
Presentation of Case: We present a rare case of hepatoid carcinoma of left adrenal gland in 70-year-old-men. Histologically, the adrenal mass was composed of cells with enlarged nuclei, proeminent nucleoli and eosinophilic cytoplasm, arranged in a pseudoglandular and thick trabecular pattern with bile plugs, which resembled hepatocellular carcinoma. The main differential diagnosis was adrenal metastasis from hepatocellular carcinoma. The adrenal gland origin of the hepatoid carcinoma was verified by the absence of liver mass on clinical and imagery grounds.
Conclusion: We present the first case of adrenal hepatoid carcinoma in Tunisia. The main differential diagnosis was adrenal metastasis from hepatocellular carcinoma, which was eliminated by the absence of liver tumor
Keywords: Hepatoid, adenocarcinoma, adrenal gland, histopathology, liver, hepatocellular carcinoma