Diagnosis of Multifocal Extranodal Rosai Dorfman Disease by Fine Needle Aspiration Cytology
Priyadarshini Biswal
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
Ipsita Dhal
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
Asaranti Kar *
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
Manjushree Nayak
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
Dilleswari Pradhan
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
Subhasini Naik
Department of Pathology, S.C.B. Medical College, Cuttack, Odisha-753007, India.
*Author to whom correspondence should be addressed.
Abstract
Rosai-Dorfman Disease (RDD) or sinus histiocytosis with massive lymhadenopathy is a rare, non- neoplastic proliferative disorder of the cells of macrophage-histiocyte family having a self limiting course. Though it affects lymphnodes commonly, it can also involve many extranodal sites. These cases can often be misdiagnosed as lymphoma. Therefore, one has to be very careful not to interpret it as lymphoma or other causes of histiocytosis because of the difference in treatment protocol. Fine needle aspiration cytology (FNAC) is a simple, fairly accurate diagnostic tool in the evaluation of such lesions.
Although large numbers of RDD cases have been reported, review of the literature has revealed very few cases diagnosed by FNAC. Here, we report a case of RDD presenting with massive bilateral cervical and submandibular lymphadenopathy along with unilateral orbital involvement, diagnosed by FNA cytology, which was subsequently confirmed by excisional biopsy and immunohistochemistry.
Keywords: Fine needle aspiration cytology, lymphadenopathy, orbital involvement, rosai-dorfman disease