Nigerian Genres of Music could be a Therapeutic Stratagem against Alcohol-induced Hippocampal Damage in Experimental Models: Evidences from Neurobehavioural, Oxidative Markers, Histochemical and Pyramidal Cell Evaluations

Main Article Content

A. O. Ajeleti
G. G. Akunna
O. Olabiyi
O. Balogun
O. H. Ayoade
V. O. Adewale

Abstract

Introduction: Memory is a cognitive function essential to everyday life. Alcohol causes damage to the hippocampus. Music (especially Mozart music) has been reported to enhance memory function.

Aim: This study investigated the possible role of different genres of Nigerian music (Afro-Hiphop and Fuji) on alcohol-induced hippocampal toxicity.

Methodology: Thirty-six (36) Adult Wistar rats (105 g-160 g) were randomly distributed into 6 groups. Group A were administered 5 ml/kg b.wt. of distilled water everyday for 28 days. Group B rats were administered 5 ml/kg b.wt. of alcohol (20%) for 2 weeks. However for the first 2 weeks, the rats in Groups C and D were administered 5 ml/kg b.wt. of alcohol (20%) and the rats in Groups E and F were exposed to Nigerian Fuji and hip hop music at 75dB-83dB respectively for 4 hours daily. For the last 2 weeks, the rats in C and D were exposed to Nigerian hip hop and fuji music respectively 75dB-83dB, for 4 hours daily and the rats in Group E and F were administered 5 ml/kg b.wt of alcohol.

Results: Higher memory capacity, oxidative status and normal histo-architecture of the hippocampus in group A rats were recorded. However, Group B rats showed a non-significant (p≥0.05) increase in body weight, higher and lower memory capacity as shown by Morris water maze test and Y-Maze respectively, significant decrease (p≤0.05) in oxidative stress markers (SOD, CAT, GSH) and a significant (p≤0.05) increase in MDA and Acetylcholinesterase, structural distortion and neuronal degeneration as evident by a significant (p≤0.05) decrease in number of pyramidal cells when compared to the rats in groups A, C-F. The rats in group C-F had changes in their memory capacity at the 14th and 28th day.

Conclusion: Music (AfroHip-Hop and Fuji) improved the histo-architecture of alcohol-distorted hippocampus in rats. However they do not have a definite effect on spatial memory.

Keywords:
Memory, neurobehaviour, Nigeria, Hiphop, music, Fuji, alcohol, Hippocampus.

Article Details

How to Cite
Ajeleti, A. O., G. Akunna, G., Olabiyi, O., Balogun, O., H. Ayoade, O., & O. Adewale, V. (2020). Nigerian Genres of Music could be a Therapeutic Stratagem against Alcohol-induced Hippocampal Damage in Experimental Models: Evidences from Neurobehavioural, Oxidative Markers, Histochemical and Pyramidal Cell Evaluations. Journal of Advances in Medicine and Medical Research, 32(1), 9-20. https://doi.org/10.9734/jammr/2020/v32i130345
Section
Original Research Article

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