Correlational Analysis of Interleukin 6, Adiponectin and Lipid Indices in Women with Uterine Fibroids

Main Article Content

Isaac Oluwole Adediji
Ayodele Ademola Adelakun
John Osaigbovoh Imaralu
Emmanuel Olusegun Ileoma
Esther Ngozi Adejumo
Adeolu Sunday Oluremi
Muibat Adesola Adeniran
Chioma Diana Okam
Oluwadamilola Gbemisola Aweda


Background: Uterine fibroids are the most common benign, monoclonal tumours affecting women of reproductive age.

Aim: This study investigated the association between interleukin-6 (IL-6), adiponectin (ADP) and lipid indices in women with uterine fibroids.

Subjects and Methods: Sixty (60) participants were recruited for this study. They comprised thirty (30) subjects who had ultrasonographic evidence of uterine fibroids and thirty (30) subjects who had no ultrasonographic evidence of uterine fibroids. Subjects were recruited from the Gynaecology out-patient clinic of LAUTECH Teaching Hospital Ogbomoso, Nigeria. Anthropometric measurements were performed using standard method. About 5 mL of venous blood was collected from each study participant and was dispensed into a plain bottle. Serum was obtained after clotting and centrifugation and was aliquoted into a small vial which was stored at     -20°C until time of analysis. Interleukin-6 (IL-6), adiponectin (ADP), total cholesterol (TC), triglycerides (TG) and high density lipoprotein (HDL) were determined using enzyme linked immunosorbent assay (ELISA) and colorimetric method as appropriate. Low density lipoprotein (LDL) was estimated using Friedewald’s equation. Data analysis was done using Student’s t-test for comparison of variables and Pearson’s correlation was used to determine the relationship between variables. P–value less than 0.05 was considered significant.

Results: Women with uterine fibroids had significantly elevated body mass index (BMI), waist circumference (WC) and waist-hip ratio (WHR) when compared with the controls (P<0.05). The mean values of TC, TG, LDL and IL-6 were significantly elevated in women with uterine fibroids when compared with the control subjects (P<0.05). Women with uterine fibroids had significantly reduced levels of ADP when compared with controls (P<0.05) and there was no significant difference in the levels of HDL when both case and control subjects were compared (P>0.05). Interleukin-6 had a significant positive correlation with BMI, WC, WHR, TC, TG and LDL. Interleukin-6 also had a significant negative correlation with HDL and ADP.

Conclusion: This study demonstrated a significant direct relationship between IL-6 and dyslipidemia in women with uterine fibroids. Also, we observed a noteworthy inverse relationship between IL-6 and adiponectin in women with uterine leiomyomas, thus emphasizing the low grade chronic inflammatory state, associated with uterine leiomyomas.

Uterine leiomyoma, interleukin-6, adiponectin, adipocytes, lipid profile.

Article Details

How to Cite
Adediji, I., Adelakun, A., Imaralu, J., Ileoma, E., Adejumo, E., Oluremi, A., Adeniran, M., Okam, C., & Aweda, O. (2019). Correlational Analysis of Interleukin 6, Adiponectin and Lipid Indices in Women with Uterine Fibroids. Journal of Advances in Medicine and Medical Research, 30(6), 1-7.
Original Research Article


Reis F, Bloise E, Ortiga-Carvalho T. Hormones and pathogenesis of uterine fibroid. Journal Best Practice & Research Clinical Obstetrics and Gynaecology. 2015;34:13-24.

Eltoukhi HM, Modi MN, Weston M, Armstrong AY, Stewart EA. The health disparities of uterine fibroid tumors for African American women: A public health issue. Am J Obstet Gynecol. 2014;210: 194-199.

Andrea Ciavattini, Jacopo DiGiuseppe, Piergiorgio Stortoni, Nina Montik, Stefano Giannubilo, Pietro Litta, Md. SorifulIslam, Andrea Tranquilli, Fernando Reis, Pasquapina Ciarmela. Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction. Obs & Gyne Int. 2013;2013:1-11.

Protic O, Toti P, Islam S, Occhini R, Giannubilo R, Catherino H, Cinti S, Petraglia F, Ciavattini A, Castellucci M, et al. Possible involvement of inflammatory/ reparative processes in the development of uterine fibroids. Cell Tissue Res. 2016;364: 415–427.

Ukwenya V, Maduemezia N, Afolayan O, Alese O, Thomas W. Prevalence of uterine fibroid in a South-Western Nigerian population: A sonographic study. Journal of Exp & Clin. Anat. 2015;14(1):24-29.

Ying Z, Weiyuan Z. Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A:B. Gynecological Endocrinology. 2009;25(8):520–523.

Ishikawa H, Ishi K, Serna V. Progesterone is essential for maintenance and growth of uterine leiomyoma. Endocrinology. 2010;151(24):33-42.

Yin P, Lin Z, Cheng Y, et al. Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells. Journal of Clinical Endocrinology and Metabolism. 2007;92(11):4459–4466.
Arici A, Sozen I. Transforming growth factor-