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Inflammatory joint diseases are characterised by significant bone and cartilage destruction, leading to disability and reduced life quality. Some of these illnesses have a systemic character which leads to life-threatening conditions. The exact mechanisms that are involved in joint pathology are still not yet known, as a variety of cell types are implicated in them. Increasing evidence shows that megakaryocytes and platelets are key players in joint inflammation and bone remodeling, and in the accompanying systemic disorders such as thrombocytosis. Here we summarise the available data on the megakaryopoiesis, megakaryocyte distribution and discuss some aspects of their involvement in inflammatory joint diseases.